Effects of Synthetic Hydroxy Isothiocyanates on Microbial Systems.
نویسندگان
چکیده
منابع مشابه
Effects of synthetic hydroxy isothiocyanates on microbial systems.
Hydroxy isothiocyanates (ITCs), including some new derivatives of naturally occurring compounds, were synthesized and their minimum inhibitory, minimum fungicidal, and minimum bactericidal concentrations for Aspergillus niger, Aspergillus fumigatus, Staphylococcus aureus, and Escherichia coli were estimated. These compounds were strongly antimicrobial; for example, 2-(4-hydroxyphenyl) ethyl ITC...
متن کاملHydroxy Isothiocyanates
antifungal and antibacterial activities at concentrations of 7.8 to 15,6uglml, respectively, and that a possible target of the ITC compounds might be the cellular sulfhydryl group, In recent years, a number of multidrug transporters have been found in various organisms including bacteria and human cells.3) A promising way to conquer such multidrug resistance is to inactivate the eMux protein in...
متن کاملNoteParadoxical Effect of Synthetic Action of Aminoglycosides Hydroxy JSsu Isothiocyanates on Antimicrobial
antimicrobial synergism with streptomycin (SM) against Escherichia coli. On the course of those experiments, a peculiar suppression of SM by a low concentration of hlTC was observed, besides the antibacterial synergism of hlTC with SM. Further, bactericidal actiyity of SM in physiological saline was reduced by addition of hlTC. Time course experiments proyed that the antagonistic effect of hlTC...
متن کاملParadoxical effect of synthetic hydroxy isothiocyanates on antimicrobial action of aminoglycosides.
Hydroxy isothiocyanates, especially 2-(4-hydroxyphenyl)ethyl isothiocyanate (hITC), were examined for antimicrobial synergism with streptomycin (SM) against Escherichia coli. On the course of those experiments, a peculiar suppression of SM by a low concentration of hITC was observed, besides the antibacterial synergism of hITC with SM. Further, bactericidal activity of SM in physiological salin...
متن کاملEffect of synthetic hydroxy isothiocyanates on a bacterial virus and DNA.
The Effect of hydroxy isothiocyanates on a bacterial virus and M13 DNA was examined. Hydroxy-substituted phenyl and phenyl alkyl isothiocyanates, especially 2-(3,4-dihydroxyphenyl)ethyl isothiocyanate(IT-Dop) synthesized from dopamine, showed antiviral activity on psiK. In transfection experiments with M13 mp DNA species, IT-Dop inhibited the single-stranded (SS) molecule more effectively than ...
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ژورنال
عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry
سال: 1998
ISSN: 0916-8451,1347-6947
DOI: 10.1271/bbb.62.491